http://hdl.handle.net/11508/11719 2026-05-04T09:14:44Z http://hdl.handle.net/11508/9902 The effects of Juniperus oxycedrus ssp oxycedrus essential oil on memory, anxiety and depression in amnesic rats Akbaba, Emel; Othman, Safeen Ahmed; Bağcı, Eyüp In the present study, memory-enhancing, anxiolytic and antidepressant-like activities of Juniperus oxycedrus ssp oxycedrus (Cupressaceae) essential oil on scopolamine-induced amnesic rats are assessed. Scopolamine is a drug comprising highly amnesic properties; therefore it has been used to create dementia animal model. Scopolamine is known to induce memory impairment as well as anxiety and depressive-like behavior in animals and humans. In this study, we evaluated the neuroprotective effects of Juniperus oxycedrus ssp oxycedrus essential oil in scopolamine treated rats. Two different doses, 1% and 3%, of essential oil were administrated to the rats by inhalation for 21 continuous days prior to the behavioral analysis. Y-maze task and radial arm maze task were used to evaluate spatial memory performances of the rats. As expected, scopolamine treated rats exhibited the following: decreases in spontaneous alternation percentage in Y-maze task, and increases in working memory errors and reference memory errors in radial arm maze task. Juniperus oxycedrus ssp oxycedrus essential oil treated rats exposed to scopolamine showed significant improvement in spatial memory function as compared to scopolamine-alone treated rats. Furthermore, anxiety and depressive like symptoms were assessed by elevated plus maze task and forced swimming task. Juniperus oxycedrus ssp oxycedrus essential oil inhalation significantly increased the number of open arm entries in elevated plus maze, indicating anxiolytic behavior. The essential oil also reduced the immobility time and increased the swimming time in forced swimming test indicating antidepressant activity. Taken together, Juniperus oxycedrus ssp oxycedrus essential oil could be a good candidate for the treatment of dementia and deserves further investigation 2017-09-29T00:00:00Z http://hdl.handle.net/11508/9901 Memory-enhancing, anxiolytic and antidepressant effects of inhaled Achillea pseudoaleppica essential oil on scopolamine-induced amnesic rats Akbaba, Emel; Bağcı, Eyüp Achillea pseudoaleppica (Asteraceae) is an endemic plant species of Turkey. Several species of the genus has been used in folk medicine in the treatment of wounds, bleedings, headache, inflammation, pains, spasmodic diseases, flatulence and dyspepsia. In the present study, memory-enhancing, anxiolytic and antidepressant- like activities of A. pseudoaleppica essential oil on scopolamine-induced amnesic rats are assessed. In order to evaluate memory- enhancing activities of A. pseudoaleppica essential oil (1% and 3%, for 21 continuous days) Y-maze and radial arm maze tasks were used. As expected, scopolamine administration decreased spontaneous alternation percentage in Y-maze test and increased the number of working memory errors and the number of reference memory errors in radial arm-maze test. A. pseudoaleppica essential oil used in this study displayed an improved effect on acquisition of the short-term memory of scopolamine-treated rats within the Y-maze task as evidenced by increased spontaneous alternation percentage. A. pseudoaleppica essential oil administered rats also showed significant improvement of reference memory formation, but not working memory formation in radial arm maze test. Furthermore, A. pseudoaleppica essential oil induced anxiolytic effect on elevated plus maze test as evidenced by increased percentage of open arm time, open arm entries and the number of crossings as compared to scopolamine-alone treated rats. A. pseudoaleppica essential oil also exhibited antidepressant-like effects as evidenced by decreased immobility time on forced-swimming test. These results suggest the neuroprotective potential of Achillea pseudoaleppica essential oil on scopolamine-induced amnesia in rats and could act as a promising therapeutic agent for the neurological abnormalities related to Alzheimer's disease. 2017-10-29T00:00:00Z http://hdl.handle.net/11508/9851 Composition of essential oil two medicinal plants (Eucalyptus camaldulensis dehnh. and vibirnum opulus l.) Doğan, Gülden; Akbaba, Emel; Kılıç, Ömer Eucalyptus is one of the world’s important and most widely planted species belongs to the family Myrtaceae. Several species of Eucalyptus are used in folk medicine as an antiseptic and against infections of the upper respiratory tract, such as cold, influenza and sinus congestion. The essential oil of Eucalyptus species showed a wide spectrum of antimicrobial, antifungal, anticandidal, antibacterial, expectorant and cough stimulant activity. In this study, the chemical composition of the essential oil from the leaves and fruits of Eucalyptus camaldulensis Dehnh. and aerial parts of Vibirnum opulus L. grown in Mersin (Turkey) were analyzed by using GC and GC/MS techniques. The yields of essential oils were 1.2% in leaf and 1.0% (v/w) in fruit of E. camaldulensis and identified representing 93.8% and 99.0% of the total oils, respectively. The major constituents of leaves were p-cymene (42.1%), eucalyptol (1,8-cineole, - -terpinol (10.7%), and in fruit were eucalyptol (1,8 cineole) (34.5%), p- -terpinol (15.1%). Our results showed that both oils has rich in terms of monoterpene hydrocarbons and oxygenated monoterpenes. Viburnum opulus is from Adoxaceae family and it is reported that has anticancer, antiaging and antioxidant activity. This species used for renal stone reduction. The yields of essential oil of V. opulus was 0.5% - - pinene (27.2%) and butanoic acid (15.8%) were the main compounds identified in the oil of Vibirnum opulus. 2017-05-14T00:00:00Z http://hdl.handle.net/11508/9850 Memory-enhancing, anxiolytic and antidepressant effects of inhaled Achillea biebersteinii essential oil on scopolamine-induced amnesic rats Akbaba, Emel; Bağcı, Eyüp; A. Hassan, Salam In this study, we investigated the possible neuroprotective effects of Achillea biebersteinii (Asteraceae) volatile oil. The plant is a shrub, distributed in South-west Asia, South-eastern Europe, and Northern Africa. It is an aromatic and medicinal plant and has been used traditionally to treat several conditions in Turkey and in the World. The present research investigates the memory enhancing, anxiolytic and antidepressant effects of Achillea biebersteinii essential oil on scopolamineinduced amnesic rats. Y-maze and radial arm maze tasks were used for evaluating memory formation. Likewise, anxiety and depressive-like behavior were conducted by elevated plus-maze and forced swimming tasks, respectively. Scopolamine-treated rats reduced memory formation as evidenced by decreased spontaneous alternation percentage in Y-maze test, and increased working memory errors and reference memory errors in radial-arm maze test. Achillea biebersteinii volatile oil significantly increased spontaneous alternation percentage, and decreased the working memory errors and reference memory errors. Furthermore, scopolamine-alone treated rats exhibited anxiety and depressive-like behavior as evidenced by reduced percentage of open arm time, number of open arm entries and number of crossings in the elevated plus maze and the swimming time and immobility time in the forced-swimming test. Achillea biebersteinii volatile oil increased the percentage of open arm time, number of open arm entries and number of crossings in the elevated plus maze, and increased the swimming time and decreased the immobility time in the forced-swimming test in scopolamine administered rats as compared to scopolamine-alone treated rats. Hence, this study suggests that the multiple exposures of Achillea biebersteinii volatile oil ameliorate scopolamine-induced spatial memory formation, anxiety and depressive-like behavior. In conclusion, Achillea biebersteinii essential oil may be useful alternative or complementary choice in either the protection or the treatment of neurodegenerative diseases such as Alzheimer's disease. 2017-05-14T00:00:00Z