Regulation of immune response with signaling lymphocyte activation molecule related receptors: Review

Abstract

The (SLAM)-related receptors (SRR) group includes CD150 (SLAM), CD244 (2134), CD84, CD299 (Ly-9), NTB-A (Ly-108), and CD319 (CRACC: CD2-like receptor-activating cytotoxic cells). Several adaptive proteins including SLAM associated protein (SAP) have a major role in the signal transduction of the SRR group. These receptors are expressed on many immune system cells. SAP deletion causes many defects in the cellular signaling. X-linked lymphoproliferative syndrome (XLP), which is a severe immune disorder, is the result of SAP deficiency. SRR receptors also may play a significant role in autoimmune diseases such as systemic lupus erythematosis (SLE), rheumatoid arthritis (RA) and in tuberculosis. Here, we review the current understanding of SRR function in different immune cells.