Leishmania tropica: The effect of darkness and light on biological activities in vitro

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dc.contributor.authorAllahverdiyev, Adil M.
dc.contributor.authorKoc, Rabia Cakir
dc.contributor.authorAtes, Sezen Canim
dc.contributor.authorBagirova, Malahat
dc.contributor.authorElcicek, Serhat
dc.contributor.authorOztel, Olga Nehir
dc.date.accessioned2026-08-12T17:22:13Z
dc.date.issued2011
dc.departmentFırat Üniversitesi
dc.description.abstractLeishmania parasites can be exposed to effects of light in their vectors and hosts, at various periods. However, there is no information about the effects of light on Leishmania parasites. The aim of this study is to investigate the effects of light on various cell parameters of Leishmania tropica, in vitro. All experiments were conducted on L. tropica promastigotes and amastigote-macrophage cultures, using flow cytometric analysis, MU and phenol-sulfuric acid assay. DAPI and Giemsa. The results showed that the morphology of parasites has changed; the cell cycle has been affected and this caused parasites to remain at G0/G1 phase. Furthermore the proliferation, infectivity, glucose consumption and mitochondrial dehydrogenase activities of parasites were decreased. Thus, for the first time, in this study, the effects of light on biological activities of Leishmania parasites were shown. These new information about parasites' biology, would be very important to investigate the effects of light on the parasites in infected vectors and hosts. (C) 2011 Elsevier Inc. All rights reserved.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)
dc.description.sponsorshipThe authors thank Andrea K. Boggild (Tropical Diseases Unit, University Health Network-Toronto General Hospital, Toronto, Canada) for giving suggestions this manuscript. The authors gratefully acknowledge, TUBITAK (The Scientific and Technological Research Council of Turkey) for financial support.
dc.identifier.doi10.1016/j.exppara.2011.04.002
dc.identifier.endpage323
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.issue4
dc.identifier.orcid0000-0002-7031-5986
dc.identifier.orcid0000-0002-8545-9878
dc.identifier.orcid0000-0003-2196-7053
dc.identifier.pmid21510933
dc.identifier.startpage318
dc.identifier.urihttps://doi.org/10.1016/j.exppara.2011.04.002
dc.identifier.urihttps://hdl.handle.net/11508/54250
dc.identifier.volume128
dc.identifier.wosWOS:000293670400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofExperimental Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectLeishmania
dc.subjectParasitology
dc.subjectLight
dc.titleLeishmania tropica: The effect of darkness and light on biological activities in vitro
dc.typeArticle

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