High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis

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dc.contributor.authorBilek, Furkan
dc.contributor.authorErcan, Zubeyde
dc.contributor.authorDeniz, Gulnihal
dc.contributor.authorOzgul, Sinem
dc.contributor.authorDemir, Caner Feyzi
dc.date.accessioned2026-08-12T17:21:34Z
dc.date.issued2024
dc.departmentFırat Üniversitesi
dc.description.abstractThe study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.
dc.description.sponsorshipErzurum Technical University Sci-entific Research Projects Coordinatorship Office [2022-008]
dc.description.sponsorshipFunding This study was supported by the Erzurum Technical University Sci-entific Research Projects Coordinatorship Office (Project Grant No: 2022-008) .
dc.identifier.doi10.1016/j.jneuroim.2024.578434
dc.identifier.issn0165-5728
dc.identifier.issn1872-8421
dc.identifier.orcid0000-0002-5944-8841
dc.identifier.orcid0000-0002-2861-2418
dc.identifier.pmid39178495
dc.identifier.scopus2-s2.0-85201719589
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2024.578434
dc.identifier.urihttps://hdl.handle.net/11508/53974
dc.identifier.volume395
dc.identifier.wosWOS:001301486100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Neuroimmunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectMultiple sclerosis
dc.subjectMMP-9
dc.subjectHigh-intensity interval exercise
dc.subjectBiomarker
dc.titleHigh-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis
dc.typeArticle

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