Genetic diversity and haplotypes of paediatric hydatid cyst isolates and first occurrence of E. canadensis (G6/G7) in paediatric cases in Turkey

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dc.contributor.authorBakal, Unal
dc.contributor.authorCelik, Figen
dc.contributor.authorSimsek, Sami
dc.contributor.authorKesik, Harun Kaya
dc.contributor.authorGunyakti Kilinc, Seyma
dc.date.accessioned2026-08-12T17:36:07Z
dc.date.issued2021
dc.departmentFırat Üniversitesi
dc.description.abstractCystic echinococcosis (CE) is a neglected zoonotic tropical disease caused by Echinococcus granulosus sensu lato. The aim of this study was to investigate the genetic variation of hydatid cyst isolates obtained from surgically confirmed paediatric cases originating from two different regions in eastern Turkey. Seventeen paediatric cases aged between 6 and 16 were operated by open surgery, and the germinal layers of their cysts were obtained for further molecular analyses. After genomic DNA isolation, 875 bp mt-CO1 gene fragments were amplified in all samples by PCR. Then, the unidirectional sequence analyses of the PCR products were carried out. According to the BLAST analyses of 17 sequences, 16 of these sequences were matched with E. granulosus sensu stricto, while one sequence was identified as E. canadensis (G6/G7) for the first time in paediatric cases in Turkey. High haplotype diversity and low nucleotide diversity were observed in the E. granulosus s.s. sequences.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [119O014]
dc.description.sponsorshipThis study was partially supported by a grant (119O014) from the Scientific and Technical Research Council of Turkey (TUBITAK).
dc.identifier.doi10.1017/S0031182021001098
dc.identifier.endpage1489
dc.identifier.issn0031-1820
dc.identifier.issn1469-8161
dc.identifier.issue12
dc.identifier.orcid0000-0002-2188-0196
dc.identifier.orcid0000-0001-8454-1901
dc.identifier.orcid0000-0002-3567-326X
dc.identifier.pmid34187611
dc.identifier.scopus2-s2.0-85108995903
dc.identifier.scopusqualityQ1
dc.identifier.startpage1482
dc.identifier.urihttps://doi.org/10.1017/S0031182021001098
dc.identifier.urihttps://hdl.handle.net/11508/57808
dc.identifier.volume148
dc.identifier.wosWOS:000693438000011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge Univ Press
dc.relation.ispartofParasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260511
dc.subjectEchinococcus granulosus sensu stricto
dc.subjecthaplotype analysis
dc.subjectpaediatric hydatid cyst
dc.titleGenetic diversity and haplotypes of paediatric hydatid cyst isolates and first occurrence of E. canadensis (G6/G7) in paediatric cases in Turkey
dc.typeArticle

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