Protective effect of luteolin on acute lung injury in a rat model of sepsis

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dc.contributor.authorCelebi, Demet
dc.contributor.authorAydin, Pelin
dc.contributor.authorCinar, Irfan
dc.contributor.authorKutlu, Zerrin
dc.contributor.authorCalik, Ilknur
dc.contributor.authorHalici, Zekai
dc.contributor.authorBayraktutan, Zafer
dc.date.accessioned2026-08-12T17:05:45Z
dc.date.issued2021
dc.departmentFırat Üniversitesi
dc.description.abstractWe investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-alpha and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties.
dc.identifier.doi10.1080/10520295.2020.1846787
dc.identifier.endpage585
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8
dc.identifier.orcid0000-0002-4324-5943
dc.identifier.orcid0000-0002-6279-9810
dc.identifier.pmid33176504
dc.identifier.scopus2-s2.0-85096133064
dc.identifier.scopusqualityQ2
dc.identifier.startpage579
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1846787
dc.identifier.urihttps://hdl.handle.net/11508/49240
dc.identifier.volume96
dc.identifier.wosWOS:000588516300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectAntioxidants
dc.subjectcecal ligation
dc.subjectIL-10
dc.subjectinflammation
dc.subjectluteolin
dc.subjectrat
dc.subjectsepsis
dc.subjectTNF-alpha
dc.titleProtective effect of luteolin on acute lung injury in a rat model of sepsis
dc.typeArticle

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