Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats

Basit Öğe Kaydı
dc.contributor.authorPoyrazoglu, Orhan Kursat
dc.contributor.authorBahcecioglu, Ibrahim Halil
dc.contributor.authorAtaseven, Huseyin
dc.contributor.authorMetin, Kerem
dc.contributor.authorDagli, Adile Ferda
dc.contributor.authorYalniz, Mehmet
dc.contributor.authorUstundag, Bilal
dc.date.accessioned2026-08-12T17:45:27Z
dc.date.issued2008
dc.departmentFırat Üniversitesi
dc.description.abstractTo assess the role of unfiltered coffee upon carbon tetrachloride (CCl(4)) induced hepatotoxicity in rats. All rats were randomly divided into control group, CCl(4)-treated, unfiltered coffee-treated and CCl(4)/unfiltered coffee-treated. Hepatic damage was induced by repeated intraperitoneal injections of CCl(4) every other day. Unfiltered coffee was given as drinking fluid for 8 days starting the day before CCl(4) administration. Liver enzymes, plasma and liver tissue malondialdehyde were analyzed. Histopathological evaluation of liver sections was performed. Serum aminotransferase level significantly increased in CCl(4)/unfiltered coffee-treated group compared to CCl(4)-treated group, as well as, lipid peroxidation products in the plasma and liver tissue. In addition, histopathological findings including inflammation and necrosis were significantly confirmed these findings. Unfiltered coffee potentiates acute liver injury in rats with CCl(4)-induced hepatotoxicity.
dc.identifier.doi10.1007/s10753-008-9092-0
dc.identifier.endpage413
dc.identifier.issn0360-3997
dc.identifier.issue6
dc.identifier.orcid0000-0003-4841-8644
dc.identifier.orcid0000-0001-7776-4154
dc.identifier.orcid0000-0001-6621-2450
dc.identifier.orcid0000-0001-9629-7002
dc.identifier.pmid19009339
dc.identifier.scopus2-s2.0-56649117368
dc.identifier.scopusqualityQ1
dc.identifier.startpage408
dc.identifier.urihttps://doi.org/10.1007/s10753-008-9092-0
dc.identifier.urihttps://hdl.handle.net/11508/60691
dc.identifier.volume31
dc.identifier.wosWOS:000262615000006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectcoffee
dc.subjectacute liver injury
dc.subjectcarbon tetrachloride
dc.subjectlipid peroxidation
dc.titleEffect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu