Serum Level Of The Soluble CD 40 Lıgand And Mean CorpuscularVolume, Mean Platellet Volume In Patıents Wıth Ischemıc AndHemorrhagıc Cerebrovascular Dısease

Abstract

INTRODUCTION: The clinical importance of biochemical indicators as well as imaging methods in diagnosisand prognosis of cerebrovascular disorder increase continuously. The aim of the present study is to determine therelationship among soluble-CD40 ligand, mean platelet volume (MPV), mean red blood cell volume (MCV) levelsand early prognosis in ischemic and hemorrhagic stroke. METHODS: 100 ischemic and 80 hemorrhagic stroke patients and 50 healthy volunteers were included in thestudy. Demographic data, Glasgow Coma Scale, intraserebral hemorrhage scale and NIH Stroke Scale/Scoreresults for stroke, hemoglobin, MPV, MCV and sCD40L measurement results were enrolled. RESULTS: MPV levels for patients with ischemic and hemorrhagic stroke were significantly higher than thecontrol group. There was no a significant correlation between blood MCV/serum sCD40L levels and strokes.sCD40L levels for exitus patients was statistically significantly lower when compared to sCD40L levels in livingpatients. DISCUSSION AND CONCLUSION: MPV levels in patients with stroke increase considerably. The low levelof sCD40L may be a parameter associated with early unfavorable prognosis and mortality.