The relationship between the heart-type fatty acid binding protein levels, carotid intima media thickness and epicardial fat thickness in patients with obstructive sleep apnea syndrome

Abstract

Introduction: In this study, we aimed to evaluate the relationship between carotid artery intima-media thickness, epicardial fat thickness measurement and the levels of heart-type fatty acid binding protein (hFABP) in patients with obstructive sleep apnea syndrome (OSAS). Materials and Methods: Ninety-nine newly diagnosed OSAS patients and fifty non-OSAS control subjects were enrolled in this study. In both groups, demographic data such as age, sex, body mass index (BMI) were recorded and carotid intima-media thickness (CMIT) and epicardial fat thickness (EFT) were measured. hFABP levels were determined using the enzyme-linked immuno-sorbent assay (EUSA) method according to the manufacturer's protocols. Results: Patients with OSAS 67% male, 33% female gender is determined. The mean age of control group was 43.28 +/- 12.12 years and group of OSAS was 47.85 +/- 11.55 years (p< 0.026). In OSAS group; 38 mild OSAS (38.38%), 23 moderate OSAS (23.23%) and 38 severe OSAS (38.38%) patients were identified. In OSAS patients, average of apnea hypopnea index AHI) was 29.83/hours. A positive correlation was observed between BMI with EFT and CMIT (p< 0.05). hFABP levels in OSAS group average was 2.65 +/- 2.1 ng/mL and in control group average was 1.62 +/- 0.90 ng/mL and this was statistically significant (p= 0.002). EFT, in the control group average was 5.3 +/- 2.04 mm, while the average was 4.3 +/- 1.79 mm in the OSAS group (p= 0.019). The correlation was observed between the CMII and EFT (p< 0.001). I here was no significant difference in BMI and gender between OSAS and control groups. No accompanying cardiovascular disease was detected in patients with OSAS. Conclusion: This study suggests EFT and hFABP can be used as a predictive value in determining cardiovascular risk in OSAS patients.