Effects of Systemic Zoledronic Acid Application on Bone Implant Connection of Titanium Implants After The Osseointegration Period

Abstract

Objective: This study examined the effects of systemic zoledronic acid (ZA) application on bone implant connection (BIC) of titanium implants after the 4 weeks osseointegration period. Materials and Methods: Twenty one adult female Wistar albino rats were used in the study. The machined surface titanium implants were surgically integrated in the corticocancellous bone of metaphyseal part of the right femur of the rats. Next, the rats were divided randomly into 3 groups: control (n=7); only titanium implants were integrated in right femoral bones and rats received no further treatment during the 8 weeks experimental period. ZA dose 1 group (n=7); and ZA dose 2 group (n=7). A single dose systemic ZA applications were done in the treatment groups, 0.1 mg/kg and 0.2 mg/kg, respectively after the 4 week osseointegration period. After 4 weeks from the ZA application and 8 weeks of the experimental period, the rats were killed, and the implants and the surrounding bone tissues were harvested, and BIC ratios (%) were analysed according to nondecalcified histological procedures. Results: Bone implant connection ratio was higher in the ZA treatment groups when compared to the controls (P<0.05), but no statistically significant differences were detected between the treatment groups (P>0.05). Conclusion: These data suggest that the single dose application of ZA after the osseointegration period could improve BIC.