Synthesis and antimicrobial activity of new thiazole-2(3H)-thiones containing 1,1,3-trisubstituted cyclobutane

Abstract

The reaction of potassium salts of RNHCSSK with 2-chloro-1-(3-methyl-3-phenylcyclobutyl)ethan-1-one in ethanol at 78-80degreesC afforded new 1,3-thiazole-2(3H)-thiones containing 1,1,3-trisubstituted cyclobutane rings at C-4. The antimicrobial activities of these compounds were also investigated against seven different microorganisms, and some of them were found to be active against several of the microorganisms at higher concentrations.