The Ameliorative Effects of Propolis against Cyclosporine A Induced Hepatotoxicity and Nephrotoxicity in Rats

Abstract

This study was planned to determine the effects of propolis in rats applied Cyclosporine A (CsA). In this study, 24 male Sprague-Dawley rats were used. Rats were randomly divided into 4 groups including control and 3 treatment groups. Group 1 (Control) were no supplement; CsA (group 2) were given as s.c. 15 mg/kg body weight (BW) every day; Propolis (group 3) were given by gavage 100 mg/kg BW every day; CsA+Propolis (group 4) were given as s.c. 15 mg/kg BW of CsA and by gavage 100 mg/kg BW of propolis every day. The feed intake were significantly higher (P<0.01) in Control and Propolis groups than CsA and CsA+Propolis groups within time period of 21 days. Further, body weight was significantly lower (P<0.01) in groups administrated with CsA (Group 2 and 4) than the other groups. Cortisol, AST, ALT and urea levels in serum of Control, Propolis and CsA+Propolis groups were found significantly lower (P<0.01) than those of CsA group. Malondialdehyde levels in kidney and liver tissues were significantly higher (P<0.01) than in the CsA groups compared to other groups. The catalase and reduced glutathione activities in kidney tissue of CsA+Propolis group were significantly higher (P<0.01) than those of CsA group. The present study demonstrated that propolis provided amelioration in terms of hepatotoxicity and nephrotoxicity consisting rats applied to CsA.