Ocular side effects of antiphysicotic agents

Abstract

Ocular complications caused by antiphysicotic agents studied on 47 patients (average age 37.8) who were under medical treatment at least one year. Average time for drug use was 4.87 years (± 4.38), mostly used medications were phenotiazine and butyrophenon, in the great majority of cases, two agents were used in combination. Frequently established ocular changes were conjunctival pigmentation (19.5%) lenticular opacities (8.7%) and retinal pigment clumpings (2.2%). Compared with healthy controls, well cooperated patients showed diminished mean sensitivity and increased defect scores in computerized perimetric examination which were all statistically significant (p<0.05).