An Investigation of The Effect of Extracellular Vesicles Isolated from Mouse Embryonic Fibroblasts on Wound Healing in an Experimental Diabetic Mouse Model

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dc.contributor.authorBozkurt, Ahmet S.
dc.contributor.authorKaplan, Davut S.
dc.contributor.authorCeribasi, Ali O.
dc.contributor.authorOrkmez, Mustafa
dc.contributor.authorCanak, Asuman
dc.contributor.authorTarakcioglu, Mehmet
dc.date.accessioned2026-08-12T17:20:04Z
dc.date.issued2022
dc.departmentFırat Üniversitesi
dc.description.abstractThis study aimed to investigate the effects of Extracellular Vesicles (EV) secreted from mouse embryonic fibroblasts EV on wound healing of full-thickness skin defect in a diabetic mouse model. The study included both in vitro and in vivo experimental studies 82 mice. In the in vitro stage of the experimental study, hysterectomy was performed on two mice between the 13-14th days of pregnancy and then EV was isolated by cell culturing. VEGF, IL-6, and TNF-alpha biomarkers were examined in tissue homogenate. Moreover, tissue taken from wound area was also subjected to histopathologic scoring. EV augmented the effect of VEGF. Therefore promoted angiogenesis increases the transport of cells, essential oxygen and nutrients in the wound area. Extracellular vesicles isolated from mouse embryonic fibroblasts have been found to accelerate wound healing in diabetes. The findings obtained from this experimental study indicate that EV isolated from mouse embryonic fibroblasts accelerate the wound healing process in experimentally induced-diabetes in mice.
dc.description.sponsorshipResearch Project Management Unit University of Gaziantep [TF. DT.18.13]
dc.description.sponsorshipWe gratefully thank the Research Project Management Unit University of Gaziantep (Grant: TF. DT.18.13) for funding this study. No potential conflict of interest relevant to this article was reported. Research Project Management Unit University of Gaziantep.
dc.identifier.doi10.1590/0001-3765202120201562
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.issue1
dc.identifier.orcid0000-0002-6096-4042
dc.identifier.orcid0000-0001-5255-0504
dc.identifier.orcid0000-0002-2398-8264
dc.identifier.orcid0000-0003-4663-209X
dc.identifier.orcid0000-0003-2428-0978
dc.identifier.pmid35107516
dc.identifier.scopus2-s2.0-85123973483
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/0001-3765202120201562
dc.identifier.urihttps://hdl.handle.net/11508/53430
dc.identifier.volume94
dc.identifier.wosWOS:000752703300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcad Brasileira de Ciencias
dc.relation.ispartofAnais Da Academia Brasileira de Ciencias
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260511
dc.subjectmouse
dc.subjectembryonic
dc.subjectfibroblast
dc.subjectextracellular
dc.subjectvesicles
dc.titleAn Investigation of The Effect of Extracellular Vesicles Isolated from Mouse Embryonic Fibroblasts on Wound Healing in an Experimental Diabetic Mouse Model
dc.typeArticle

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