Hybrid CNN Based Computer-Aided Diagnosis System for Choroidal Neovascularization, Diabetic Macular Edema, Drusen Disease Detection from OCT Images

Abstract

In the treatment of eye diseases, optical coherence tomography (OCT) is a medical imaging method that displays biological tissue layers by taking high resolution tomographic sections at the micron level. It has an important role in the diagnosis and follow-up of many diseases such as Choroidal Neovascularization (CNV), Diabetic Macular Edema (DME), age-related macular degeneration (AMD), Diabetic Retinopathy, Central Serous Retinopathy, Epiretinal Membrane, and Macular Hole. Computer-Aided Diagnostic (CAD) tools are needed in early detection and treatment monitoring of such eye diseases. In this paper, a hybrid Convolutional Neural Networks-based CAD system, which can classify Diabetic Macular Edema (DME), Drusen Choroidal Neovascularization (CNV), and normal OCT images, is proposed. The proposed system is CNN-SVM (Convolutional Neural Networks - Support Vector Machine) model and doesn't require any additional extraction of feature or noise filtering on OCT images. A total of 968 OCT images is classified in pre-trained CNN methods with Alexnet, Resnetl8 and Googlenet. Accuracy is achieved with highest Googlenet 97.4%. To examine the performance of the proposed CAD system, the CNNSVM method achieves 98.96% with the highest accuracy hybrid Alexnet-SVM model, which is implemented with Alexnet-SVM, Resnet18-SVM and Googlenet-SVM models.