Selenium Modulates Oxidative Stress-Induced TRPM2 Cation Channel Currents in Transfected Chinese Hamster Ovary Cells

Basit Öğe Kaydı
dc.contributor.authorNaziroglu, Mustafa
dc.contributor.authorOzgul, Cemil
dc.contributor.authorKucukayaz, Mustafa
dc.contributor.authorCig, Bilal
dc.contributor.authorHebeisen, Simon
dc.contributor.authorBal, Ramazan
dc.date.accessioned2026-08-12T17:31:47Z
dc.date.issued2013
dc.departmentFırat Üniversitesi
dc.description.abstractIt has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood. We investigated the effects of selenium on H2O2-induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques.
dc.description.sponsorshipUnit of Scientific Research Project, Suleyman Demirel University [BAP: 2881-YL-11]
dc.description.sponsorshipMN formulated the present hypothesis and was responsible for writing the report. CO, MK and BC were responsible for analysis of the data. SH made critical revision on the manuscript. The study was partially supported by Unit of Scientific Research Project, Suleyman Demirel University (BAP: 2881-YL-11). There is no conflict of interest in the current study. The authors thank Professor James W. Putney (NIH, NC, USA) for scientific and English revision of the manuscript.
dc.identifier.doi10.1111/j.1742-7843.2012.00934.x
dc.identifier.endpage102
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue2
dc.identifier.orcid0000-0003-3829-8669
dc.identifier.orcid0000-0001-9403-2844
dc.identifier.orcid0000-0003-0887-6974
dc.identifier.pmid22905852
dc.identifier.scopus2-s2.0-84872144486
dc.identifier.scopusqualityQ2
dc.identifier.startpage96
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2012.00934.x
dc.identifier.urihttps://hdl.handle.net/11508/56391
dc.identifier.volume112
dc.identifier.wosWOS:000313240600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260511
dc.subjectHydrogen-Peroxide
dc.subjectAdp-Ribose
dc.subjectCalcium Influx
dc.subjectQuantum Dots
dc.subjectCa2+ Influx
dc.subjectActivation
dc.subjectBrain
dc.subjectInhibition
dc.subjectApoptosis
dc.subjectToxicity
dc.titleSelenium Modulates Oxidative Stress-Induced TRPM2 Cation Channel Currents in Transfected Chinese Hamster Ovary Cells
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu