Effects of vitamin E against aluminum neurotoxicity in rats

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dc.contributor.authorNedzvetsky, VS
dc.contributor.authorTuzcu, M
dc.contributor.authorYasar, A
dc.contributor.authorTikhomirov, AA
dc.contributor.authorBaydas, G
dc.date.accessioned2026-08-12T17:02:29Z
dc.date.issued2006
dc.departmentFırat Üniversitesi
dc.description.abstractThe present study examined the protective effects of vitamin E against aluminum - induced neurotoxicity in rats. Wistar rats were given daily aluminum via their drinking water containing 1600 mg/liter aluminum chloride for six weeks. Aluminum induced a significant increase in lipid peroxidation (LPO) in hippocampus and frontal cortex. Furthermore, aluminum caused marked elevation in the levels of the glial markers (glial fibrillary acidic protein (GFAP) and S 10013) and proinflammatory cytokines (TNF-alpha and IL-1 beta) in both brain areas. Vitamin E treatment reduced the contents of glial markers and cytokines and the levels of LPO. In conclusion, this study demonstrates that vitamin E ameliorates glial activation and reduces release of proinflammatory cytokines induced by aluminum.
dc.identifier.doi10.1134/S0006297906030023
dc.identifier.endpage244
dc.identifier.issn0006-2979
dc.identifier.issn1608-3040
dc.identifier.issue3
dc.identifier.orcid0000-0002-1329-3143
dc.identifier.orcid0000-0003-2063-4636
dc.identifier.orcid0000-0001-7352-441X
dc.identifier.orcid0000-0002-9206-3177
dc.identifier.orcid0000-0002-1277-5976
dc.identifier.pmid16545059
dc.identifier.scopus2-s2.0-33645292306
dc.identifier.scopusqualityQ2
dc.identifier.startpage239
dc.identifier.urihttps://doi.org/10.1134/S0006297906030023
dc.identifier.urihttps://hdl.handle.net/11508/48186
dc.identifier.volume71
dc.identifier.wosWOS:000236376400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPleiades Publishing Ltd
dc.relation.ispartofBiochemistry-Moscow
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectaluminum
dc.subjectvitamin E
dc.subjectglial fibrillary acidic protein
dc.subjectS100B protein
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.titleEffects of vitamin E against aluminum neurotoxicity in rats
dc.typeArticle

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