Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca2+ channels in brain and dorsal root ganglion in rat

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dc.contributor.authorNaziroglu, M.
dc.contributor.authorCelik, O.
dc.contributor.authorOzgul, C.
dc.contributor.authorCig, B.
dc.contributor.authorDogan, S.
dc.contributor.authorBal, R.
dc.contributor.authorPariente, J. A.
dc.date.accessioned2026-08-12T17:31:28Z
dc.date.issued2012
dc.departmentFırat Üniversitesi
dc.description.abstractWe aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system. Ca2+ influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+ melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca2+ values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca2+ influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca2+ channels. (C) 2011 Elsevier Inc. All rights reserved.
dc.description.sponsorshipUnit of Scientific Research Project, Suleyman Demirel University [BAP: 2531-M-10]
dc.description.sponsorshipMN formulated the present hypothesis and was responsible for writing the report. OC, CO, BC, and SD were responsible for analysis of the data. RB, NG, ABR and JAP made critical revision to the manuscript. The authors thank Assist. Prof. Dr. Selcuk Comlekci (Electronics and Communication Engineering Department, Suleyman Demirel University, Isparta, Turkey) for calculation of SAR values in the setup of the experiment. There is no conflict of interest in the study. The study was partially supported by Unit of Scientific Research Project, Suleyman Demirel University (NO: BAP: 2531-M-10).
dc.identifier.doi10.1016/j.physbeh.2011.10.005
dc.identifier.endpage692
dc.identifier.issn0031-9384
dc.identifier.issue3
dc.identifier.orcid0000-0003-0887-6974
dc.identifier.orcid0000-0003-3829-8669
dc.identifier.orcid0000-0001-6063-0504
dc.identifier.orcid0000-0001-9403-2844
dc.identifier.orcid0000-0002-9262-996X
dc.identifier.orcid0000-0002-9094-9943
dc.identifier.pmid22019785
dc.identifier.scopus2-s2.0-80155214092
dc.identifier.scopusqualityQ1
dc.identifier.startpage683
dc.identifier.urihttps://doi.org/10.1016/j.physbeh.2011.10.005
dc.identifier.urihttps://hdl.handle.net/11508/56257
dc.identifier.volume105
dc.identifier.wosWOS:000300076500011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhysiology & Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectMelatonin
dc.subjectCa2+ influx
dc.subjectDorsal root ganglion neuron
dc.subjectElectroencephalography records
dc.subjectOxidative stress
dc.subjectTRPM2 channels
dc.subjectWireless devices
dc.titleMelatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca2+ channels in brain and dorsal root ganglion in rat
dc.typeArticle

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