Histological assessment of liver and stomach damage caused by pyridazinone derivative antidepressant agents

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dc.contributor.authorOzdemir, Zeynep
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorTaslidere, Elif
dc.contributor.authorVardi, Nigar
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2026-08-12T17:06:44Z
dc.date.issued2022
dc.departmentFırat Üniversitesi
dc.description.abstractDepression is a serious psychological disorder that affects a significant population. We investigated the antidepressant activities of four pyridazinone derivatives that contain the hydrazide moiety using the forced swimming test (FST). The compounds tested exhibited good antidepressant activity compared to duloxetine. The most promising compound was compound 2, which reduced the duration of immobility during FST. The toxic effects of the four compounds on the histomorphology of the liver and stomach tissue also was evaluated.
dc.description.sponsorshipInonu University Scientific Researches Unit [2011/80]
dc.description.sponsorshipThis project was supported by Inonu University Scientific Researches Unit [Project no. 2011/80].
dc.identifier.doi10.1080/10520295.2021.1999499
dc.identifier.endpage362
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5
dc.identifier.orcid0000-0003-1208-4072
dc.identifier.orcid0000-0001-8827-8557
dc.identifier.orcid0000-0003-4559-2305
dc.identifier.orcid0000-0003-1723-2556
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.pmid34842474
dc.identifier.scopus2-s2.0-85120041827
dc.identifier.scopusqualityQ2
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1999499
dc.identifier.urihttps://hdl.handle.net/11508/49358
dc.identifier.volume97
dc.identifier.wosWOS:000723469500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectAntidepressant
dc.subjecthistopathology
dc.subjectliver
dc.subjectmice
dc.subjectpyridazinone
dc.subjectstomach
dc.subjectswimming test
dc.titleHistological assessment of liver and stomach damage caused by pyridazinone derivative antidepressant agents
dc.typeArticle

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