Immunostaining characteristics of irisin in benign and malignant renal cancers

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dc.contributor.authorKuloglu, T.
dc.contributor.authorArtas, G.
dc.contributor.authorYardim, M.
dc.contributor.authorSahin, I
dc.contributor.authorAydin, Y.
dc.contributor.authorBeyoglu, N.
dc.contributor.authorAydin, S.
dc.date.accessioned2026-08-12T17:05:14Z
dc.date.issued2019
dc.departmentFırat Üniversitesi
dc.description.abstractWe investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis.
dc.identifier.doi10.1080/10520295.2019.1586998
dc.identifier.endpage441
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6
dc.identifier.orcid0000-0001-9874-3838
dc.identifier.orcid0000-0003-4028-2041
dc.identifier.pmid30896263
dc.identifier.scopus2-s2.0-85063135437
dc.identifier.scopusqualityQ2
dc.identifier.startpage435
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1586998
dc.identifier.urihttps://hdl.handle.net/11508/49038
dc.identifier.volume94
dc.identifier.wosWOS:000483618700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectCancer
dc.subjectchromophobe RCC
dc.subjectclear cell RCC
dc.subjectFuhrman nuclear grade
dc.subjectirisin
dc.subjectoncocytoma
dc.subjectrenal tissue
dc.titleImmunostaining characteristics of irisin in benign and malignant renal cancers
dc.typeArticle

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