Hydroxytyrosol has a protective effect on the kidneys through dardarin and spexin

Abstract

OBJECTIVE: In this study, the possible role of dardarin and spexin in the protective effect of hydroxytyrosol (HT) against corn syrup-induced renal injury in rats was investigated. METHODS: Rats were categorized into four groups (n=6) as control, HT, corn syrup, and corn syrup+HT. Over 6 weeks, rats were administered water infused with 30% corn syrup, 4 ml/kg/day solution containing HT was administered, both independently and in conjunction with corn syrup, throughout the 6 weeks. The molecular parameters of dardarin and spexin in the renal tissue were assessed through histopathological examination. Biochemical parameters were also examined with the ELISA Method. RESULTS: In this study, it was observed that the dardarin and spexin levels increased in the control group as a result of the administration of corn syrup. After HT treatment, it was observed that the dardarin and spexin levels decreased. The increase in glucose, amylase, and lipase levels because of corn syrup consumption decreased with hydroxytyrosol consumption. The increase in erythrocyte extravasation, exudate accumulation, and fibrosis in kidney tissue observed as a result of corn syrup decreased as a result of HT administration. CONCLUSION: It is thought that the protective effect of HT against damage to the renal due to corn syrup consumption may be mediated by dardarin and spexin.