MRI histogram analysis of optic nerves in children with type 1 neurofibromatosis

Abstract

Background/Aim: Type 1 neurofibromatosis (NF1) is the most common neurocutaneous disease affecting numerous systems. Optic pathway glioma (OPG) is a common tumor in children with NF1 and often has variable clinical presentations. In this study, histogram analysis parameters of optic nerves were measured in the magnetic resonance images (MRI) of children with NF1 and compared with a control group. Methods: This case-control study consisted of three groups: Ten patients with NF1 without optic pathway glioma (bilateral optic nerve, n: 20), four patients with NF1 with bilateral optic pathway glioma (n: 8), and nineteen healthy controls (n: 38). ROIs were placed on bilateral pre-chiasmatic optic nerves in the images. With histogram analysis, average gray level intensity (mean), the standard deviation, minimum, median, and maximum intensity, uniformity, entropy, kurtosis, variance, skewness, size% M, size% U, size% L, and percentiles were measured. Results: Mean, median, 3%, 5%, 10%, 25%, and 75% values were higher in NF1 patients with optic pathway glioma (NF1-OPG) than in NF1 patients without optic pathway glioma (NF1-woOPG), and the control group (P