Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats

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dc.contributor.authorYener, Zabit
dc.contributor.authorCelik, Ismail
dc.contributor.authorIlhan, Fatma
dc.contributor.authorBal, Ramazan
dc.date.accessioned2026-08-12T17:30:08Z
dc.date.issued2009
dc.departmentFırat Üniversitesi
dc.description.abstractThis study was carried out to investigate the hepatoprotective and antioxidant properties of Urtica dioica L seeds (LIDS) extract against aflatoxin (AF)-exposure in rats. The preventive potential and antioxidant capacity of the plant's extract was evaluated by liver histopathological changes, measuring serum marker enzymes, antioxidant defense systems and lipid peroxidation (Malondialdehyde, MDA) content in some tissues of rats. Eighteen rats were randomly divided into one of three experimental groups: control, AF-treated group and AF+UDS-treated group. Rats in control group were fed with a diet without AF. Rats in AF-treated group and AF+UDS-treated group received approximately 25 mu gr of AF/rat/day. AF+UDS groups also received 2 mL of LIDS oils/rat/day by gavage for 90 days. Administration of LIDS extract restored the AF-induced imbalance between MDA and antioxidant system towards near normal particularly in liver. Hepatoprotection by LIDS is further substantiated by the almost normal histologic findings in AF+UDS-treated group as against degenerative changes in the AF-treated rats. It is concluded that LIDS has a hepatoprotective effect in rats with aflatoxicosis, probably acting by promoting the antioxidative defense systems. (C) 2008 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipThe Scientific and Technical Research Council of Turkey (TUBITAK) [104 V 139)]
dc.description.sponsorshipThe authors are grateful to The Scientific and Technical Research Council of Turkey (TUBITAK) (Project No: 104 V 139) for providing financial assistance during the tenure of Research Associateship.
dc.identifier.doi10.1016/j.fct.2008.11.031
dc.identifier.endpage424
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue2
dc.identifier.orcid0000-0002-6365-5843
dc.identifier.orcid0000-0003-3829-8669
dc.identifier.orcid0000-0003-0363-6285
dc.identifier.pmid19073231
dc.identifier.scopus2-s2.0-58149495967
dc.identifier.scopusqualityQ1
dc.identifier.startpage418
dc.identifier.urihttps://doi.org/10.1016/j.fct.2008.11.031
dc.identifier.urihttps://hdl.handle.net/11508/55973
dc.identifier.volume47
dc.identifier.wosWOS:000263429800024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260511
dc.subjectAflatoxicosis
dc.subjectUrtica dioica L seed
dc.subjectHistopathology
dc.subjectBiochemistry
dc.subjectRat
dc.titleEffects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats
dc.typeArticle

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