In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines
| dc.contributor.author | Sancar, Pelin Yılmaz | |
| dc.contributor.author | Taskin, Irmak Icen | |
| dc.date.accessioned | 2026-08-12T15:36:09Z | |
| dc.date.issued | 2024 | |
| dc.department | Fırat Üniversitesi | |
| dc.description.abstract | The Fumaria L. species (Papaveraceae), is known colloquially as “Şahtere”. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-(4.5-dimethylthiazol -2-il)-2.5-diphenyltetrazolium bromide (MTT). While the results showed that F. asepala and F. schleicheri subsp. microcarpa's methanolic extracts presented a meaningful decrease in the vitality of colon (HCT-116) cancer cells, no cytotoxic effect was achieved on lung (A549) cancer and brain (sh-sy5) cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells (Beas-2B). | |
| dc.identifier.doi | 10.46810/tdfd.1287018 | |
| dc.identifier.endpage | 29 | |
| dc.identifier.issn | 2149-6366 | |
| dc.identifier.issue | 2 | |
| dc.identifier.startpage | 25 | |
| dc.identifier.trdizinid | 1257123 | |
| dc.identifier.uri | https://doi.org/10.46810/tdfd.1287018 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay/1257123 | |
| dc.identifier.uri | https://hdl.handle.net/11508/34845 | |
| dc.identifier.volume | 13 | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.relation.ispartof | Türk Doğa ve Fen Dergisi | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK// | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_TR-Dizin_20260511 | |
| dc.subject | A549 | |
| dc.subject | Fumaria | |
| dc.subject | Cytotoxic | |
| dc.subject | Beas-2B | |
| dc.subject | sh-sy5 | |
| dc.subject | HCT116 | |
| dc.title | In Vitro Cytotoxic Effects of Some Fumaria L. (Papaveraceae) Species Methanolic Extracts on Cancer Cell Lines | |
| dc.type | Article |
